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AMOTL2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - AMOTL2 Antibody (Center) AP8860C
    All lanes : Anti-AMOTL2 Antibody (Center) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: A375 whole cell lysate Lane 3: HUVEC whole cell lysate Lane 4: Caco2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 86 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9Y2J4
Other Accession G3V735, Q8K371, F1MRK3
Reactivity Human, Mouse
Predicted Rat, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Additional info
Gene ID 51421
Other Names Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989
Target/Specificity This AMOTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-152 amino acids from the Central region of human AMOTL2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAMOTL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMOTL2
Synonyms KIAA0989
Function Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Cellular Location Recycling endosome.
Research Areas
Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.
Author : Proszynski TJ1, Sanes JR.
J Cell Sci. 2013 May 15;126(Pt 10):2225-35. doi: 10.1242/jcs.121327. Epub 2013 Mar 22.
23525008

BACKGROUND

AMOTL2 is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.

REFERENCES

Bratt,A.,et.al., Gene 298 (1), 69-77 (2002)

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