|Application ||IHC-P, WB|
|Calculated MW||H=116 KDa|
|Other Names||Caspase recruitment domain-containing protein 6; CARD6|
|Target/Specificity||This CARD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human CARD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CARD6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in apoptosis.|
Provided below are standard protocols that you may find useful for product applications.
CARD6 is a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Kim,S.S., et.al., Pathology 42 (1), 50-53 (2010)
Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)