|Application ||IHC-P, WB|
|Calculated MW||M=105;H=105 KDa|
|Other Names||Tyrosine-protein kinase transmembrane receptor ROR2, mROR2, Neurotrophic tyrosine kinase, receptor-related 2, Ror2|
|Target/Specificity||This Mouse Ror2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 756-790 amino acids from the C-terminal region of human Mouse Ror2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ror2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (PubMed:10700181). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
Provided below are standard protocols that you may find useful for product applications.
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (By similarity).
Oishi I.,et al.Genes Cells 4:41-56(1999).
Church D.M.,et al.PLoS Biol. 7:E1000112-E1000112(2009).
DeChiara T.M.,et al.Nat. Genet. 24:271-274(2000).
van Wijk N.V.,et al.Biochem. Biophys. Res. Commun. 390:211-216(2009).