|Calculated MW||H=84,83,80 KDa|
|Other Names||MICOS complex subunit MIC60, Cell proliferation-inducing gene 4/52 protein, Mitochondrial inner membrane protein, Mitofilin, p87/89, IMMT, HMP, MIC60, MINOS2|
|Target/Specificity||This IMMT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 170-203 amino acids from the Central region of human IMMT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IMMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HMP, MIC60, MINOS2|
|Function||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion|
Provided below are standard protocols that you may find useful for product applications.
Icho T.,et al.Gene 144:301-306(1994).
Gieffers C.,et al.Exp. Cell Res. 232:395-399(1997).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kim J.W.,et al.Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.