癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Rat Serpinh1 Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P29457 |
| Other Accession | P19324, P50454, Q2KJH6 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 134CT3.1.1 |
| Calculated MW | 46518 Da |
| Antigen Region | 222-251 aa |
| Gene ID | 29345 |
|---|---|
| Other Names | Serpin H1, 47 kDa heat shock protein, Collagen-binding protein, Colligin, GP46, Serpinh1, Cbp1, Hsp47 |
| Target/Specificity | This Rat Serpinh1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the Central region of rat Serpinh1. |
| Dilution | IHC-P~~1:100~500 WB~~ 1:4000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Rat Serpinh1 Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Serpinh1 |
|---|---|
| Synonyms | Cbp1, Hsp47 |
| Function | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. |
| Cellular Location | Endoplasmic reticulum lumen. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis. Kakugawa T, et al. Virchows Arch, 2010 Mar. PMID 20094730. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. Zhou B, et al. J Clin Invest, 2009 Jun. PMID 19411759. Adenovirus-mediated RNA interference against collagen-specific molecular chaperone 47-KDa heat shock protein suppresses scar formation on mouse wounds. Wang Z, et al. Cell Biol Int, 2008 May. PMID 18093850. Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Ishida Y, et al. Mol Biol Cell, 2006 May. PMID 16525016.
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