癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Autophagy Receptor Motif PlotterDeveloped by Abcepta, Copyright © 2014 -2025
The autophagy pathway is mediated by selective receptors. They recognize and sort diverse cargo substrates (e.g., proteins, organelles, pathogens) for delivery to the autophagic machinery. Known autophagy receptors are characterized by short linear sequence motifs (autophagy receptor motifs, or ARMs) responsible for the interaction with the Atg8/LC3 family. Many ARM-containing proteins (ARM-CPs) are also involved in autophagosome formation and maturation and a few of them in regulating signaling pathways. The availability of an ever-increasing number of complete eukaryotic genomes poses a grand challenge for characterizing novel ARM-CPs. ARM, a freely available web resource developed by Abcepta scientists, assists in the identification of novel ARM-CPs. Users input a given an amino acid sequence into the web-enabled tool, and ARM identifies internal sequences matching a pattern within the 3 classes of the extended ARM motif (x6-W/F/Yxxx-x2). The program then computes and lists the top four scores for each motif class (W-, F-, Y-). The full sequence of the ARM-CP is displayed, where ARMs are colored by their score and ranked score-values are presented in tabular form. Users citing this tool when used in the development of a publication are recommended to adhere to the rules of the publishing entity in referring to this resource.
| References: |
Noda et al (2010) FEBS Letters 584: 1379-85 PMID:20083108 Birgisdottir et al (2013) J Cell Sci 126: 3237-47 PMID:23908376 Rogov et al (2014) Molecular Cell 53: 167-78 PMID:24462201 |