|Application ||WB, E|
|Calculated MW||77329 Da|
|Other Names||Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2|
|Target/Specificity||This TGM2 monoclonal antibody is generated from mouse immunized with TGM2 recombinant protein.|
|Format||Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TGM2 antibody ( Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.|
Provided below are standard protocols that you may find useful for product applications.
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
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Kim, D.S., et al. Biochem. Biophys. Res. Commun. 399(2):300-306(2010)
Stamnaes, J., et al. J. Biol. Chem. 285(33):25402-25409(2010)
Santhanam, L., et al. Circ. Res. 107(1):117-125(2010)
Kumar, A., et al. PLoS ONE 5 (10), E13390 (2010) :