DPF2 antibody (Ascites)
Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, E |
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Primary Accession | Q92785 |
Other Accession | NP_006259.1 |
Reactivity | Human, Hamster |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG3,K |
Clone Names | 226CT14.1.1.2 |
Calculated MW | 44155 Da |
Gene ID | 5977 |
---|---|
Other Names | Zinc finger protein ubi-d4, Apoptosis response zinc finger protein, BRG1-associated factor 45D, BAF45D, D4, zinc and double PHD fingers family 2, Protein requiem, DPF2, BAF45D, REQ, UBID4 |
Target/Specificity | This DPF2 monoclonal antibody is generated from mouse immunized with DPF2 recombinant protein. |
Dilution | WB~~ 1:8000 E~~Use at an assay dependent concentration. |
Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DPF2 antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DPF2 |
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Synonyms | BAF45D, REQ, UBID4 |
Function | Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:27775714, PubMed:28533407). Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407). Might also have a role in the development and maturation of lymphoid cells (By similarity). Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684). |
Cellular Location | Nucleus. Cytoplasm |
Tissue Location | Ubiquitous. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
REFERENCES
Tando, T., et al. J. Biol. Chem. 285(29):21951-21960(2010)
Matsuyama, R., et al. J. Biol. Chem. 285(24):18166-18176(2010)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

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