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>   首页   >   产品   >   一抗   >   神经科学   >   HNMT Antibody   

HNMT Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - HNMT Antibody AM2023b
    HNMT Antibody (Cat. #AM2023b) western blot analysis in HepG2 cell line lysates (35μg/lane).This demonstrates the HNMT antibody detected the HNMT protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P50135
Other Accession NP_008826.1
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 432CT31.4.2
Calculated MW 33295 Da
Additional info
Gene ID 3176
Other Names Histamine N-methyltransferase, HMT, HNMT
Target/Specificity Purified His-tagged HNMT protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:100~1000
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHNMT Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNMT
Function Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Cellular Location Cytoplasm.
Research Areas

BACKGROUND

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

REFERENCES

Stevenson, J., et al. Am J Psychiatry 167(9):1108-1115(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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