癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SWAP70 Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UH65 |
| Other Accession | NP_055870.2 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 434CT16.5.5 |
| Calculated MW | 68998 Da |
| Gene ID | 23075 |
|---|---|
| Other Names | Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640 |
| Target/Specificity | Purified His-tagged SWAP70 protein(Fragment) was used to produced this monoclonal antibody. |
| Dilution | WB~~1:1000~8000 |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SWAP70 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SWAP70 |
|---|---|
| Synonyms | KIAA0640 |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium Cytoplasm, cytoskeleton. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760) |
| Tissue Location | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
REFERENCES
Liu, J., et al. J. Histochem. Cytochem. 55(7):701-708(2007)
Ihara, S., et al. J. Cell. Sci. 119 (PT 3), 500-507 (2006) :
Kimbara, N., et al. Microbiol. Immunol. 50(3):235-242(2006)
Hilpela, P., et al. Mol. Biol. Cell 14(8):3242-3253(2003)
Rapalus, L., et al. Clin. Immunol. 101(3):270-275(2001)
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