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SWAP70 Antibody(Ascites)

Mouse Monoclonal Antibody (Mab)

     
  • 1 - SWAP70 Antibody(Ascites) AM2029a
    SWAP70 Antibody (Cat. #AM2029a) western blot analysis in MDA-MB231 cell line lysates (35μg/lane).This demonstrates the SWAP70 antibody detected the SWAP70 protein (arrow).
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Product info
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9UH65
Other Accession NP_055870.2
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 434CT16.5.5
Calculated MW 68998 Da
Additional info
Gene ID 23075
Other Names Switch-associated protein 70, SWAP-70, SWAP70, KIAA0640
Target/Specificity Purified His-tagged SWAP70 protein(Fragment) was used to produced this monoclonal antibody.
Dilution WB~~1:1000~8000
Format Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSWAP70 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SWAP70
Synonyms KIAA0640
Function Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Cellular Location Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium Cytoplasm, cytoskeleton. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760)
Tissue Location Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)
Research Areas

BACKGROUND

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

REFERENCES

Liu, J., et al. J. Histochem. Cytochem. 55(7):701-708(2007)
Ihara, S., et al. J. Cell. Sci. 119 (PT 3), 500-507 (2006) :
Kimbara, N., et al. Microbiol. Immunol. 50(3):235-242(2006)
Hilpela, P., et al. Mol. Biol. Cell 14(8):3242-3253(2003)
Rapalus, L., et al. Clin. Immunol. 101(3):270-275(2001)

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