癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Myoglobin Antibody
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P02144 |
| Other Accession | P02189, P02150, NP_005359.1 |
| Reactivity | Human, Mouse |
| Predicted | Monkey, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 444CT19.2.1 |
| Calculated MW | 17184 Da |
| Antigen Region | 103-130 aa |
| Gene ID | 4151 |
|---|---|
| Other Names | Myoglobin, MB |
| Target/Specificity | This Myoglobin antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from human Myoglobin. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Myoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MB (HGNC:6915) |
|---|---|
| Function | Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218). |
| Cellular Location | Cytoplasm, sarcoplasm |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.
REFERENCES
Esquerra, R.M., et al. Phys Chem Chem Phys 12(35):10270-10278(2010)
Endeward, V., et al. Cardiovasc. Res. 87(1):22-29(2010)
Balobanov, V.A., et al. Mol. Biol. (Mosk.) 44(4):708-717(2010)
Kristiansen, G., et al. Br. J. Cancer 102(12):1736-1745(2010)
Rayner, B.S., et al. Biochem. J. 423(2):169-177(2009)
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