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Myoglobin Antibody

Mouse Monoclonal Antibody (Mab)

     
  • 1 - Myoglobin Antibody AM2032b
    Myoglobin Antibody (Cat. #AM2032b) western blot analysis in mouse heart and skeletal muscle tissue lysates (35μg/lane).This demonstrates the Myoglobin antibody detected the Myoglobin protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession P02144
Other Accession P02189, P02150, NP_005359.1
Reactivity Human, Mouse
Predicted Monkey, Pig
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 444CT19.2.1
Calculated MW 17184 Da
Antigen Region 103-130 aa
Additional Information
Gene ID 4151
Other Names Myoglobin, MB
Target/Specificity This Myoglobin antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 103-130 amino acids from human Myoglobin.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMyoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MB (HGNC:6915)
Function Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218).
Cellular Location Cytoplasm, sarcoplasm
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported.

REFERENCES

Esquerra, R.M., et al. Phys Chem Chem Phys 12(35):10270-10278(2010)
Endeward, V., et al. Cardiovasc. Res. 87(1):22-29(2010)
Balobanov, V.A., et al. Mol. Biol. (Mosk.) 44(4):708-717(2010)
Kristiansen, G., et al. Br. J. Cancer 102(12):1736-1745(2010)
Rayner, B.S., et al. Biochem. J. 423(2):169-177(2009)

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