癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VTN Antibody(Ascites)
Mouse Monoclonal Antibody (Mab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P04004 |
| Other Accession | NP_000629.3 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM |
| Clone Names | 389CT23.2.1.3 |
| Calculated MW | 54306 Da |
| Antigen Region | 352-379 aa |
| Gene ID | 7448 |
|---|---|
| Other Names | Vitronectin, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, VTN |
| Target/Specificity | This VTN antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 352-379 amino acids from human VTN. |
| Dilution | WB~~1:500~1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VTN Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VTN |
|---|---|
| Function | Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
| Cellular Location | Secreted, extracellular space |
| Tissue Location | Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834). Expressed in plasma (at protein level) (PubMed:2448300). Expressed in serum (at protein level) (PubMed:29567995). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Chillakuri, C.R., et al. FEBS Lett. 584(15):3287-3291(2010)
Sa E Cunha, C., et al. PLoS Pathog. 6 (5), E1000911 (2010) :
Kellouche, S., et al. Tumour Biol. 31(2):129-139(2010)
Singh, B., et al. Mol. Microbiol. 75(6):1426-1444(2010)
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