癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LOX Antibody (Center) (Ascites)
Mouse Monoclonal Antibody (Mab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P28300 |
| Other Accession | P16636, P45845, P28301, NP_002308.2 |
| Reactivity | Human |
| Predicted | Mouse, Pig, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 624CT23.7.3 |
| Calculated MW | 46944 Da |
| Antigen Region | 234-260 aa |
| Gene ID | 4015 |
|---|---|
| Other Names | Protein-lysine 6-oxidase, Lysyl oxidase, LOX |
| Target/Specificity | This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX. |
| Dilution | WB~~1:200~1600 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LOX Antibody (Center) (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LOX |
|---|---|
| Function | Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). |
| Cellular Location | Secreted. Secreted, extracellular space |
| Tissue Location | Heart, placenta, skeletal muscle, kidney, lung and pancreas. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Gao, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(44):18892-18897(2010)
Santhanam, A.N., et al. Oncogene 29(27):3921-3932(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :
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