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|Application ||IHC-P-Leica, WB, E|
|Other Accession||NP_001161066.1, NP_000299.2, NP_001121167.1|
|Calculated MW||54466 Da|
|Other Names||Lysosomal protective protein, Carboxypeptidase C, Carboxypeptidase L, Cathepsin A, Protective protein cathepsin A, PPCA, Protective protein for beta-galactosidase, Lysosomal protective protein 32 kDa chain, Lysosomal protective protein 20 kDa chain, CTSA, PPGB|
|Target/Specificity||This CTSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human CTSA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CTSA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.|
Author : Hossain MA1, Higaki K2, Shinpo M1, Nanba E2, Suzuki Y3, Ozono K1, Sakai N4.
Brain Dev. 2015 Aug 7. pii: S0387-7604(15)00137-0. doi: 10.1016/j.braindev.2015.07.006. [Epub ahead of print]
Provided below are standard protocols that you may find useful for product applications.
CTSA encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis.
Reich, M., et al. Immunol. Lett. 128(2):143-147(2010)
Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Tatano, Y., et al. J. Med. Invest. 53 (1-2), 103-112 (2006) :
Lewandrowski, U., et al. Mol. Cell Proteomics 5(2):226-233(2006)