CASC4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, FC, E |
---|---|
Primary Accession | Q6P4E1 |
Other Accession | Q6P2L7, NP_816929.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 49498 Da |
Antigen Region | 336-365 aa |
Gene ID | 113201 |
---|---|
Other Names | Protein CASC4, Cancer susceptibility candidate gene 4 protein, CASC4 |
Target/Specificity | This CASC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the C-terminal region of human CASC4. |
Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CASC4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GOLM2 (HGNC:24892) |
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Synonyms | CASC4 |
Cellular Location | Membrane; Single-pass type II membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Further characterization of the product of this gene may yield insight into the fundamental biology and pathogenetic effects of HER-2/neu overexpression in human breast and ovarian cancer cells. Alternatively spliced variants encoding different isoforms have been identified for this gene.
REFERENCES
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Sato, T., et al. Onkologie 26(3):268-271(2003)
Scheer, M., et al. Mund Kiefer Gesichtschir 7(3):138-145(2003)
Oh, J.J., et al. Nucleic Acids Res. 27(20):4008-4017(1999)

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