癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
WIPF2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TF74 |
| Other Accession | NP_573571.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46289 Da |
| Antigen Region | 392-419 aa |
| Gene ID | 147179 |
|---|---|
| Other Names | WAS/WASL-interacting protein family member 2, WASP-interacting protein-related protein, WIP- and CR16-homologous protein, WIP-related protein, WIPF2, WICH, WIRE |
| Target/Specificity | This WIPF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 392-419 amino acids from the C-terminal region of human WIPF2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | WIPF2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WIPF2 |
|---|---|
| Synonyms | WICH, WIRE |
| Function | Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. |
| Cellular Location | Cytoplasm, cytoskeleton Note=Localized to stress fibers and bundles of actin filaments |
| Tissue Location | Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.
REFERENCES
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)
Salazar, M.A., et al. J. Biol. Chem. 278(49):49031-49043(2003)
Aspenstrom, P. Exp. Cell Res. 279(1):21-33(2002)
Kato, M., et al. Biochem. Biophys. Res. Commun. 291(1):41-47(2002)
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