癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VWA2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q5GFL6 |
| Other Accession | NP_940898.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 82012 Da |
| Antigen Region | 44-72 aa |
| Gene ID | 340706 |
|---|---|
| Other Names | von Willebrand factor A domain-containing protein 2, A domain-containing protein similar to matrilin and collagen, AMACO, Colon cancer secreted protein 2, CCSP-2, VWA2, AMACO |
| Target/Specificity | This VWA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-72 amino acids from the N-terminal region of human VWA2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VWA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VWA2 |
|---|---|
| Synonyms | AMACO |
| Cellular Location | Secreted. |
| Tissue Location | Expression is generally absent in normal colon and other normal body tissues, but it is induced an average of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
VWA2, also named as AMACO and CCSP2, is a novel candidate serological marker of colon neoplasia. VWA2 is found in the media of variesy of established cell lines of both fibroblast and epithelial origin.
REFERENCES
Gao, W., et al. Blood 112(5):1713-1719(2008)
Gebauer, J.M., et al. J. Biol. Chem. 283(26):17846-17854(2008)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Xin, B., et al. Oncogene 24(4):724-731(2005)
Eller, E., et al. Ann. N. Y. Acad. Sci. 1037, 145-149 (2004) :
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