TBX6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IF, E |
---|---|
Primary Accession | O95947 |
Other Accession | D3ZJK7, P70327, E1BEA8, NP_004599.2 |
Reactivity | Human, Mouse, Rat |
Predicted | Rat, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47045 Da |
Antigen Region | 264-293 aa |
Gene ID | 6911 |
---|---|
Other Names | T-box transcription factor TBX6, T-box protein 6, TBX6 |
Target/Specificity | This TBX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-293 amino acids from the Central region of human TBX6. |
Dilution | WB~~1:500 IF~~1:10~50 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TBX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TBX6 |
---|---|
Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
Tissue Location | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures.
REFERENCES
Fei, Q., et al. Spine 35(9):983-988(2010)
Ghebranious, N., et al. J. Bone Miner. Res. 23(10):1576-1583(2008)
Farin, H.F., et al. J. Biol. Chem. 282(35):25748-25759(2007)
Papapetrou, C., et al. Genomics 55(2):238-241(1999)
Yi, C.H., et al. Genomics 55(1):10-20(1999)

终于等到您。ABCEPTA(百远生物)抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息,您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问,联系:0512-88856768 tech-china@abcepta.com.