癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HIPK1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q86Z02 |
| Other Accession | O88904, NP_938009.1, NP_938010.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 130843 Da |
| Antigen Region | 893-922 aa |
| Gene ID | 204851 |
|---|---|
| Other Names | Homeodomain-interacting protein kinase 1, Nuclear body-associated kinase 2, HIPK1, KIAA0630, MYAK, NBAK2 |
| Target/Specificity | This HIPK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 893-922 amino acids from the C-terminal region of human HIPK1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HIPK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIPK1 |
|---|---|
| Synonyms | KIAA0630, MYAK, NBAK2 |
| Function | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). |
| Cellular Location | Nucleus. Cytoplasm. Nucleus speckle. Note=Predominantly nuclear Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. |
| Tissue Location | Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines Isoform 2 is highly expressed in testis. Expressed in both androgen- dependent and androgen-independent prostate cancer cells (PubMed:28289210). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
REFERENCES
Matre, V., et al. Biochem. Biophys. Res. Commun. 388(1):150-154(2009)
Li, X., et al. J. Biol. Chem. 280(15):15061-15070(2005)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Song, J.J., et al. J. Biol. Chem. 278(47):47245-47252(2003)
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