癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CTTNBP2NL Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9P2B4 |
| Other Accession | Q99LJ0, NP_061174.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70158 Da |
| Antigen Region | 135-164 aa |
| Gene ID | 55917 |
|---|---|
| Other Names | CTTNBP2 N-terminal-like protein, CTTNBP2NL, KIAA1433 |
| Target/Specificity | This CTTNBP2NL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the N-terminal region of human CTTNBP2NL. |
| Dilution | IHC-P~~1:100~500 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CTTNBP2NL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CTTNBP2NL (HGNC:25330) |
|---|---|
| Synonyms | KIAA1433 |
| Function | Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). |
| Cellular Location | Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8SX68}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q99LJ0} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CTTNBP2NL may bind to cortactin, which is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. The striatin-interacting phosphatase and kinase (STRIPAK) complex establishes mutually exclusive interactions with either CTTNBP2 or CTTNBP2NL.
REFERENCES
Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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