癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SGPL1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O95470 |
| Other Accession | NP_003892.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 63524 Da |
| Antigen Region | 72-101 aa |
| Gene ID | 8879 |
|---|---|
| Other Names | Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL 1, hSPL, Sphingosine-1-phosphate aldolase, SGPL1, KIAA1252 |
| Target/Specificity | This SGPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human SGPL1. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SGPL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SGPL1 (HGNC:10817) |
|---|---|
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro- inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R0X7} |
| Tissue Location | Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SGPL1 cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
REFERENCES
Seo, Y.J., et al. J. Virol. 84(16):8124-8131(2010)
Vogel, P., et al. PLoS ONE 4 (1), E4112 (2009) :
Peest, U., et al. J. Cell. Biochem. 104(3):756-772(2008)
Morgan, A.R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :
Oskouian, B., et al. Proc. Natl. Acad. Sci. U.S.A. 103(46):17384-17389(2006)
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