IFI6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, E |
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Primary Accession | P09912 |
Other Accession | NP_002029.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 12927 Da |
Antigen Region | 5-34 aa |
Gene ID | 2537 |
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Other Names | Interferon alpha-inducible protein 6, Interferon-induced protein 6-16, Ifi-6-16, IFI6, G1P3 |
Target/Specificity | This IFI6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-34 amino acids of human IFI6(P09912-3). |
Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IFI6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IFI6 (HGNC:4054) |
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Function | Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro- apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Szegedi, K., et al. Exp. Dermatol. 19(3):269-278(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Zhao, D., et al. Virol. J. 5, 114 (2008) :
Cheriyath, V., et al. J. Clin. Invest. 117(10):3107-3117(2007)

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