癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ASAM Antibody (Center)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q9H6B4 |
| Other Accession | Q8K1G0, Q8R373, NP_079045.1 |
| Reactivity | Human, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Gene ID | 79827 |
|---|---|
| Other Names | CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein, CLMP, ACAM, ASAM |
| Target/Specificity | This ASAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human ASAM. |
| Dilution | IHC-P-Leica~~1:500 WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ASAM Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLMP |
|---|---|
| Synonyms | ACAM, ASAM |
| Function | May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development. |
| Cellular Location | Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Predominantly expressed in epithelial cells within different tissues and in the white adipose tissue Expressed at high levels in small intestine and placenta, at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney and lung and at low levels in the liver and peripheral blood leukocytes. Highly abundant in the intestine during embryo and fetal development (at protein level) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The CTX (see VSIG2, MIM 606011) family of proteins, including ASAM, are type I transmembrane proteins within the Ig superfamily that localize to junctional complexes between endothelial and epithelial cells and may play a role in cell-cell adhesion (Raschperger et al., 2004 [PubMed 14573622]).[supplied by OMIM].
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kawabata, K., et al. Gene Ther. 14(16):1199-1207(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Eguchi, J., et al. Biochem. J. 387 (PT 2), 343-353 (2005) :
Raschperger, E., et al. J. Biol. Chem. 279(1):796-804(2004)
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