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UNC5D Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6UXZ4 |
| Other Accession | NP_543148.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 105880 Da |
| Antigen Region | 483-511 aa |
| Gene ID | 137970 |
|---|---|
| Other Names | Netrin receptor UNC5D, Protein unc-5 homolog 4, Protein unc-5 homolog D, UNC5D, KIAA1777, UNC5H4 |
| Target/Specificity | This UNC5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-511 amino acids from the Central region of human UNC5D. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UNC5D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UNC5D |
|---|---|
| Synonyms | KIAA1777, UNC5H4 {ECO:0000303|Ref.2} |
| Function | Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, H., et al. Biochem. Biophys. Res. Commun. 370(4):594-598(2008)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Zhong, Y., et al. Cereb. Cortex 14(10):1144-1152(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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