癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MRAP2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96G30 |
| Other Accession | NP_612418.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23548 Da |
| Antigen Region | 58-86 aa |
| Gene ID | 112609 |
|---|---|
| Other Names | Melanocortin-2 receptor accessory protein 2, MC2R accessory protein 2, MRAP2, C6orf117 |
| Target/Specificity | This MRAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human MRAP2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MRAP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MRAP2 |
|---|---|
| Synonyms | C6orf117 |
| Function | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo. |
| Cellular Location | Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. |
| Tissue Location | Expressed in the adrenal gland and brain. Not expressed in other tissues. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The specific function of this protein remains unknown.
REFERENCES
Sebag, J.A., et al. Sci Signal 3 (116), RA28 (2010) :
Chan, L.F., et al. Proc. Natl. Acad. Sci. U.S.A. 106(15):6146-6151(2009)
Sebag, J.A., et al. J. Biol. Chem. 284(1):610-618(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Metherell, L.A., et al. Nat. Genet. 37(2):166-170(2005)
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