WDR45 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB, E |
---|---|
Primary Accession | Q9Y484 |
Other Accession | Q5U2Y0, Q91VM3, Q7ZUX3, NP_009006.2, NP_001025067.1 |
Reactivity | Human, Rat, Mouse |
Predicted | Zebrafish, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 39868 Da |
Antigen Region | 17-46 aa |
Gene ID | 11152 |
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Other Names | WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat-containing protein 45, WDR45, WDRX1, WDRXI4, WIPI4 |
Target/Specificity | This WDR45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human WDR45. |
Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WDR45 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WDR45 |
---|---|
Synonyms | WDRX1, WDRXI4, WIPI4 |
Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Binds phosphatidylinositol 3- phosphate (PtdIns3P) (PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066). |
Cellular Location | Preautophagosomal structure. Cytoplasm. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy |
Tissue Location | Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta Expression is down-regulated in pancreatic and in kidney tumors |
For Research Use Only. Not For Use In Diagnostic Procedures.

Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined.
REFERENCES
Proikas-Cezanne, T., et al. Oncogene 23(58):9314-9325(2004)
Jeffries, T.R., et al. Mol. Biol. Cell 15(6):2652-2663(2004)
Clark, A.G., et al. Science 302(5652):1960-1963(2003)

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