癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ZNF415 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q09FC8 |
| Other Accession | NP_001157781.1, NP_060825.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 68798 Da |
| Antigen Region | 155-184 aa |
| Gene ID | 55786 |
|---|---|
| Other Names | Zinc finger protein 415, ZNF415 |
| Target/Specificity | This ZNF415 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 amino acids from the N-terminal region of human ZNF415. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF415 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF415 |
|---|---|
| Function | Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and p53/TP53. |
| Cellular Location | Nucleus. Cytoplasm. Note=Isoforms 1, isoform 2, isoform 4 and isoform 5 showed both nuclear and cytoplasm localization. Isoform 3 localized only to nucleus |
| Tissue Location | Expressed in all tissues examined. Isoforms are differentially expressed. Isoform 3 and isoform 5 were highly expressed, isoform 4 moderately expressed, isoform 2 lower expression, the lowest expression level was seem with isoform 1 |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ZNF415 is involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP-1 and TP53/p53.
REFERENCES
Cheng, Y., et al. Biochem. Biophys. Res. Commun. 351(1):33-39(2006)
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Cat# AP13505a
