癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HYAL4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q2M3T9 |
| Other Accession | NP_036401.2 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54249 Da |
| Antigen Region | 143-172 aa |
| Gene ID | 23553 |
|---|---|
| Other Names | Hyaluronidase-4, Hyal-4, Chondroitin sulfate endo-beta-N-acetylgalactosaminidase, Chondroitin sulfate hydrolase, CSHY, Hyaluronoglucosaminidase-4, HYAL4 |
| Target/Specificity | This HYAL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human HYAL4. |
| Dilution | IHC-P-Leica~~N/A WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HYAL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HYAL4 |
|---|---|
| Function | Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Also has chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Detected in placenta and skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq].
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kaneiwa, T., et al. Glycobiology 20(3):300-309(2010)
Fiszer-Szafarz, B., et al. J. Biochem. Biophys. Methods 45(2):103-116(2000)
Csoka, A.B., et al. Genomics 60(3):356-361(1999)
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