癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SYT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N9I0 |
| Other Accession | P29101, P46097, NP_796376.2, NP_001129976.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46872 Da |
| Antigen Region | 243-272 aa |
| Gene ID | 127833 |
|---|---|
| Other Names | Synaptotagmin-2, Synaptotagmin II, SytII, SYT2 |
| Target/Specificity | This SYT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human SYT2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SYT2 (HGNC:11510) |
|---|---|
| Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101} |
| Tissue Location | Expressed at the neuromuscular junction (PubMed:33659639). Expressed in melanocytes (PubMed:23999003) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).
REFERENCES
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)
Han, C., et al. J. Immunol. 182(5):2986-2996(2009)
Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)
Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)
Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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