癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PIK3IP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96FE7 |
| Other Accession | NP_443112.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28248 Da |
| Antigen Region | 178-207 aa |
| Gene ID | 113791 |
|---|---|
| Other Names | Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL, PIK3IP1, HGFL |
| Target/Specificity | This PIK3IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-207 amino acids from the C-terminal region of human PIK3IP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PIK3IP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PIK3IP1 |
|---|---|
| Synonyms | HGFL |
| Function | Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PIK3IP1 is a novel protein that shares homology with the p85 subunit of phosphatidylinositol-3-Kinases (PI3Ks). The PI3K is essential for cell proliferation and Survival. The PIK3IP down regulates the activity of the PI3K and induces apoptosis by associating with p85 and p110 to form a complex, using the p85-like domain. However, there is no evidence to suggest that the PIK3IP1 prevents association of p85 and p110 as they associate with very high affinity.
REFERENCES
Gao, P., et al. Beijing Da Xue Xue Bao 40(6):572-577(2008)
He, X., et al. Cancer Res. 68(14):5591-5598(2008)
Zhu, Z., et al. Biochem. Biophys. Res. Commun. 358(1):66-72(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
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