癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Mylk3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q3UIZ8 |
| Other Accession | NP_780650.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86372 Da |
| Antigen Region | 174-203 aa |
| Gene ID | 213435 |
|---|---|
| Other Names | Myosin light chain kinase 3, Cardiac-MyBP-C-associated Ca/CaM kinase, Cardiac-MLCK, Mylk3 |
| Target/Specificity | This Mouse Mylk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the N-terminal region of mouse Mylk3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Mylk3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Mylk3 |
|---|---|
| Function | Kinase that phosphorylates MYL2 in vitro (PubMed:17885681, PubMed:18202317). Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317). Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Restricted to cardiomyocytes (at protein level). Down-regulated in heart after experimental myocardial infarction at the protein level; no significant changes at the mRNA level |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mylk3 may play a role in smooth muscle contraction (By similarity).
REFERENCES
White, R.A., et al. Blood Cells Mol. Dis. 43(2):141-148(2009)
Chan, J.Y., et al. Circ. Res. 102(5):571-580(2008)
Kim, B.J., et al. Can. J. Physiol. Pharmacol. 85(12):1254-1262(2007)
Seguchi, O., et al. J. Clin. Invest. 117(10):2812-2824(2007)
Choi, Y.O., et al. Exp. Mol. Med. 38(2):180-189(2006)
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¥ 1,250.00
Cat# AP13923A
