癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSNAX Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q99598 |
| Other Accession | Q9JHB5, Q9QZE7, Q4R599, NP_005990.1 |
| Reactivity | Human |
| Predicted | Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33112 Da |
| Antigen Region | 34-62 aa |
| Gene ID | 7257 |
|---|---|
| Other Names | Translin-associated protein X, Translin-associated factor X, TSNAX, TRAX |
| Target/Specificity | This TSNAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-62 amino acids from the N-terminal region of human TSNAX. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TSNAX Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TSNAX |
|---|---|
| Synonyms | TRAX |
| Function | Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. |
| Cellular Location | Cytoplasm, perinuclear region. Golgi apparatus. Nucleus. Note=Accumulate in the Golgi complex of mid- late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.
REFERENCES
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Schosser, A., et al. Mol. Psychiatry 15(8):844-849(2010)
Okuda, A., et al. Neuromolecular Med. 12(1):78-85(2010)
Nakata, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15873-15878(2009)
Palo, O.M., et al. Hum. Mol. Genet. 16(20):2517-2528(2007)
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