癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Mst4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q99JT2 |
| Other Accession | Q9P289, NP_598490.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46614 Da |
| Antigen Region | 271-299 aa |
| Gene ID | 70415 |
|---|---|
| Other Names | Serine/threonine-protein kinase 26, Stk26 {ECO:0000312|MGI:MGI:1917665} |
| Target/Specificity | This Mouse Mst4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the Central region of mouse Mst4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Mst4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Stk26 {ECO:0000312|MGI:MGI:1917665} |
|---|---|
| Function | Serine/threonine-protein kinase that acts as a mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9P289}. Golgi apparatus {ECO:0000250|UniProtKB:Q9P289}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner {ECO:0000250|UniProtKB:Q9P289} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Mediator of cell growth. Modulates apoptosis (By similarity).
REFERENCES
Gerhard, D.S., et al. Genome Res. 14 (10B), 2121-2127 (2004) :
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Cat# AP14072c
