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Rat TRPV3 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Rat TRPV3 Antibody (C-term) AP1425b
    Western blot analysis of TRPV3 Antibody (C-term) (Cat.#AP1425b) in HL60 cell line lysates (35ug/lane). TRPV3(arrow) was detected using the purified Pab.
  • 14 - Rat TRPV3 Antibody (C-term) AP1425b
    Formalin-fixed and paraffin-embedded human testis tissue reacted with TRPV3 Antibody (C-term) (Cat.#AP1425b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession Q4QYD9
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 90273 Da
Antigen Region 662-692 aa
Additional Information
Other Names Heat sensitive channel TRPV3
Target/Specificity This Rat TRPV3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-692 amino acids from the C-terminal region of rat TRPV3.
Dilution WB~~1:1000
IHC-P~~1:100~500
E~~Use at an assay dependent concentration.
Format Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRat TRPV3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Trpv3 {ECO:0000313|RGD:1564531}
Function Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Cellular Location Cell membrane {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lysosome {ECO:0000256|ARBA:ARBA00004371}
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

TRPV3 belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C.

REFERENCES

Frederick,J., Biochem. Biophys. Res. Commun. 358 (4), 1058-1064 (2007)
Asakawa,M., J. Invest. Dermatol. 126 (12), 2664-2672 (2006)

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