癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Myocd Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q8VIM5 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 101400 Da |
| Gene ID | 214384 |
|---|---|
| Other Names | Myocardin, Basic SAP coiled-coil transcription activator 2, SRF cofactor protein, Myocd, Bsac2, Mycd, Srfcp |
| Target/Specificity | This Mouse Myocd antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 743-777 amino acids from the C-terminal region of Mouse Myocd. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Myocd Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Myocd |
|---|---|
| Synonyms | Bsac2, Mycd, Srfcp |
| Function | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). |
| Cellular Location | Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei |
| Tissue Location | Expressed in smooth muscle cell-containing tissues (PubMed:12663482). Expressed in the heart (PubMed:11439182, PubMed:12640126, PubMed:12663482, PubMed:14645532, PubMed:20385216) Expressed in the aorta and bladder (PubMed:12640126, PubMed:12663482, PubMed:20385216). Weakly expression in the lung, testis and kidney (PubMed:14645532). Weakly expressed in the stomach (PubMed:12640126, PubMed:12663482). Weakly expressed in the intestine and colon (PubMed:12663482). [Isoform 3]: Predominantly expressed in cardiac muscle. [Isoform 5]: Predominantly expressed in smooth muscle cell-rich tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
REFERENCES
Wang D.-Z.,et al.Cell 105:851-862(2001).
Wang D.-Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002).
Ueyama T.,et al.Mol. Cell. Biol. 23:9222-9232(2003).
Sawada T.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Du K.L.,et al.Mol. Cell. Biol. 23:2425-2437(2003).
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