|Application ||WB, E|
|Calculated MW||102185 Da|
|Other Names||Protein CIP2A, Cancerous inhibitor of PP2A, p90 autoantigen, KIAA1524, CIP2A|
|Target/Specificity||This KIAA1524 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 537-567 amino acids from the Central region of human KIAA1524.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIAA1524 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm Note=Slightly concentrates in the perinuclear region (PubMed:12118381).|
|Tissue Location||Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level)|
Provided below are standard protocols that you may find useful for product applications.
Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
Soo Hoo L.,et al.Oncogene 21:5006-5015(2002).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Shi F.D.,et al.Prostate 63:252-258(2005).