癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ABCA5 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8WWZ7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 186508 Da |
| Gene ID | 23461 |
|---|---|
| Other Names | ATP-binding cassette sub-family A member 5, ABCA5, KIAA1888 |
| Dilution | WB~~ 1:1000 |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ABCA5 (HGNC:35) |
|---|---|
| Synonyms | KIAA1888 |
| Function | Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Late endosome membrane {ECO:0000250|UniProtKB:Q8K448}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8K448}. Cell membrane {ECO:0000250|UniProtKB:Q8K448}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000250|UniProtKB:Q8K448} |
| Tissue Location | Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465). {ECO:0000269|PubMed:12504089, ECO:0000269|PubMed:24831815, ECO:0000269|PubMed:25125465, ECO:0000269|Ref.1} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May play a role in the processing of autolysosomes (By similarity).
REFERENCES
Arnould I.,et al.GeneScreen 1:157-164(2001).
Petry F.,et al.Biochem. Biophys. Res. Commun. 300:343-350(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 8:179-187(2001).
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