POU5F1/OCT4 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB |
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Primary Accession | Q01860 |
Reactivity | Mouse |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2b |
Calculated MW | 38571 Da |
Gene ID | 5460 |
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Other Names | MGC22487;Oct 3;Oct 4;Oct-3;Oct-4;OCT3;Oct4;Octamer binding protein 3;Octamer binding protein 4;Octamer binding transcription factor 3;Octamer-binding protein 3;Octamer-binding protein 4;Octamer-binding transcription factor 3;OTF 3;OTF 4;OTF-3;OTF3;OTF4; PO5F1_HUMAN;POU class 5 homeobox 1;POU domain class 5 transcription factor 1;POU domain transcription factor OCT4;POU domain, class 5, transcription factor 1;POU5F1. |
Dilution | WB~~1:1000 |
Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | POU5F1 |
---|---|
Synonyms | OCT3, OCT4, OTF3 |
Function | Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. |
Cellular Location | Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. {ECO:0000250|UniProtKB:P20263, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:23024368} |
Tissue Location | Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
REFERENCES
Takeda J.,et al.Nucleic Acids Res. 20:4613-4620(1992).
Stuart P.E.,et al.Tissue Antigens 76:387-397(2010).
Shiina T.,et al.Genetics 173:1555-1570(2006).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).

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