癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Hsp70 (C-terminus) Antibody
Purified Mouse Monoclonal Antibody (Mab)
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- 实验流程
- 背景知识
Application 
| WB, IP |
|---|---|
| Primary Accession | P08107 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 70 KDa |
| Other Names | DAQB 147D11.1 001;FLJ54303;FLJ54370;FLJ54392;FLJ54408;FLJ75127;Heat shock 70 kDa protein 1;Heat shock 70 kDa protein 1/2;Heat shock 70 kDa protein 1A/1B;heat shock 70kDa protein 1A;Heat shock 70kDa protein 1B;Heat shock induced protein;heat shock protein 70;HSP70 1;HSP70 2;HSP70-1/HSP70-2;HSP70-1A;HSP70.1;HSP70.1/HSP70.2;HSP70I;HSP71_HUMAN;HSP72; HSPA1;HSPA1A;HSPA1B;XXbac BCX40G17.3 001. |
|---|---|
| Dilution | WB~~1:1000 IP~~1:500 |
| Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
REFERENCES
Milner C.M.,et al.Immunogenetics 32:242-251(1990).
Hunt C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6455-6459(1985).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
Shiina S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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