TBLR1 Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB, ICC, IHC |
---|---|
Primary Accession | Q9BZK7 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 55595 Da |
Gene ID | 79718 |
---|---|
Other Names | C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-related protein 1;TBL1R_HUMAN;TBL1XR1;Transducin (beta) like 1 X linked receptor 1;Transducin beta like 1X related protein 1;Transducin beta-like 1X-related protein 1. |
Dilution | WB~~1:1000 ICC~~1:200 IHC~~1:100 |
Format | Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.09% (W/V) sodium azide, 50%,glycerol |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TBL1XR1 |
---|---|
Synonyms | IRA1, TBLR1 |
Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. |
Cellular Location | Nucleus. |
Tissue Location | Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
REFERENCES
Zhang J.,et al.Mol. Cell 9:611-623(2002).
Zhang X.,et al.Exp. Hematol. 28:1286-1296(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Yoon H.-G.,et al.EMBO J. 22:1336-1346(2003).

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