RAB4A Antibody
Purified Mouse Monoclonal Antibody (Mab)
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Application ![]()
| WB |
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Primary Accession | P20338 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2a |
Calculated MW | 24390 Da |
Gene ID | 5867 |
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Other Names | HRES 1 / RAB4;Oncogene RAB4;OTTHUMP00000042824;Rab 4;RAB 4A;RAB4 member RAS oncogene family;RAB4A;RAB4A member RAS oncogene family;RAB4A_HUMAN;Ras related protein Rab 4A;Ras related protein Rab4A;Ras-related protein Rab-4A. |
Dilution | WB~~1:500 |
Format | Purified mouse monoclonal in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | RAB4A (HGNC:9781) |
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Synonyms | RAB4 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). |
Cellular Location | Membrane; Peripheral membrane protein. Cytoplasm Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1 |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Protein transport. Probably involved in vesicular traffic (By similarity).
REFERENCES
Zahraoui A.,et al.J. Biol. Chem. 264:12394-12401(1989).
Nagy G.,et al.J. Biol. Chem. 281:34574-34591(2006).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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Discontinued
Cat# AP52759
Size:
50 µl
100 µl
Price:
¥ 1,500.00
¥ 2,600.00
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