Anti-HtrA2/Omi Antibody
Mouse Anti Human Monoclonal Antibody
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- 实验流程
- 背景知识
Application ![]()
| WB |
---|---|
Primary Accession | O43464 |
Other Accession | NM_013247 |
Reactivity | Mouse, Hamster |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Immunogen | Recombinant human HtrA2/Omi protein. |
Purification | Affinity purified |
Calculated MW | 48841 Da |
Gene ID | 27429 |
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Other Names | High temperature requirement protein A2;HTRA 2;HtrA like serine protease;HtrA serine peptidase 2;HtrA, E. coli, homolog of, 2;HtrA2;HTRA2_HUMAN;mitochondrial;Omi stress regulated endoprotease;Omi stress-regulated endoprotease;PARK 13;PARK13;Protease serine 25;PRSS 25;PRSS25;Serine protease 25;Serine protease HTRA2;Serine protease HTRA2 mitochondrial;Serine protease htra2 mitochondrial precursor;Serine protease omi;Serine proteinase OMI. |
Dilution | WB~~1:1000 |
Format | PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | HTRA2 |
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Synonyms | OMI, PRSS25 |
Function | [Isoform 1]: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein (PubMed:10873535). Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity; or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism (PubMed:15200957). Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6 (PubMed:36758104, PubMed:36758105). Cleaves THAP5 and promotes its degradation during apoptosis (PubMed:19502560). |
Cellular Location | Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID |
Tissue Location | [Isoform 1]: Ubiquitously expressed. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an inc

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Discontinued
Cat# AP53417
Size:
50 µl
100 µl
Price:
¥ 1,500.00
¥ 2,600.00
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