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>   首页   >   产品   >   一抗   >   精选抗体   >   SARS virus PUP2 Antibody (N-term)   

SARS virus PUP2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
E
Primary Accession P59633
Other Accession NP_828853
Reactivity SARS
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 17750 Da
Additional Information
Other Names Non-structural protein 3b, ns3b, Accessory protein 3b, Protein X2, 3b
Target/Specificity This SARS virus PUP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of SARS virus PUP2.
Dilution E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSARS virus PUP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name 3b
Function Induces host cell G0/G1 arrest and apoptosis.
Cellular Location Host nucleus, host nucleolus. Host mitochondrion
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The SARS-CoV genome contains five major open reading frames (ORFs) that encode the replicase polyprotein (R), the spike (S), envelope (E), and membrane (M) glycoproteins; and the nucleocapsid protein (N). Other proteins not falling into these categories have been termed PUPs (putative uncharacterized proteins) for their unknown structural or functional features and dissimilarity to those known sequences. However, it has been found that some of the PUPs matched the entries in the NCBI database.PUP2 has a counterpart in Isolate Tor2, the ORF4. It matches 4 segments of different entries in GenBank: 138 amino acids with NADH dehydrogenase subunit2 of Laudakia stoliczkana, 137 amino acids with a hypothetical protein of Methanosarcina barkeri, 85 amino acids with myosin IXb of Homo sapiens, and 85 amino acids with MY9B HUMAN myosin IXb. All of these alignments are 28% identical.

REFERENCES

He, R., et al., Biochem. Biophys. Res. Commun. 316(2):476-483 (2004).
Snijder, E.J., et al., J. Mol. Biol. 331(5):991-1004 (2003).
Marra, M.A., et al., Science 300(5624):1399-1404 (2003).

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