癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GLRX2 Antibody (C-term T135)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | Q9NS18 |
| Other Accession | Q32L67 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Gene ID | 51022 |
|---|---|
| Other Names | Glutaredoxin-2, mitochondrial, GLRX2, GRX2 |
| Target/Specificity | This GLRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-146 amino acids from the C-terminal region of human GLRX2. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLRX2 Antibody (C-term T135) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLRX2 |
|---|---|
| Synonyms | GRX2 |
| Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. |
| Cellular Location | Isoform 1: Mitochondrion. |
| Tissue Location | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GLRX2 are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions.
REFERENCES
Lundberg M., Johansson C. J. Biol. Chem. 276:26269-26275(2001)
Gladyshev V.N., Liu A. J. Biol. Chem. 276:30374-30380(2001)
Lillig C.H. Proc. Natl. Acad. Sci. U.S.A. 101:13227-13232(2004)
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