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RAB32 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
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  • 1 - RAB32 Antibody (N-term) AW5040
    Western blot analysis of lysates from SK-BR-3, HepG2 cell line (from left to right), using RAB32 Antibody (N-term)(Cat. #AW5040). AW5040 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q13637
Other Accession NP_006825.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24997 Da
Isotype Rabbit IgG
Antigen Source HUMAN
Additional Information
Gene ID 10981
Antigen Region 2-28 aa
Other Names RAB32; Ras-related protein Rab-32
Dilution WB~~1:1000
Target/Specificity This RAB32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-28 amino acids from the N-terminal region of human RAB32.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB32 (HGNC:9772)
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:11784320, PubMed:21808068). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:11784320). Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (PubMed:38127736).
Cellular Location Mitochondrion. Mitochondrion outer membrane; Lipid-anchor. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Melanosome {ECO:0000250|UniProtKB:Q9CZE3}. Melanosome membrane. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Tissue Location Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Small GTP-binding proteins of the RAB family, such as RAB32, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).

REFERENCES

Hirota, Y., et al. Cell. Mol. Life Sci. 66(17):2913-2932(2009)
Shibata, D., et al. Int. J. Cancer 119(4):801-806(2006)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Alto, N.M., et al. J. Cell Biol. 158(4):659-668(2002)
Bao, X., et al. Eur. J. Biochem. 269(1):259-271(2002)

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