CREB Pathway
Extracellular stimuli summon changes in gene expression in target cells by activating intracellular protein kinase cascades that phosphorylate nuclear transcription factors. Transcription factor CREB1 (cyclic AMP (cAMP) responsive element binding protein 1) activates transcription of the target genes in response to a wide array of stimuli, including peptide hormones, growth factors, and neuronal activity. CREB1 is essential to a variety of cellular processes, including proliferation, differentiation, and adaptive responses. CREB proteins are critical for learning and memory and contribute to neuronal adaptation to drugs of abuse and hormonal control of metabolic processes, including regulation of gluconeogenesis by hormones glucagon and insulin.
















癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具,可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分,识别结合到自噬通路中的蛋白是非常重要的,便于让我们理解自噬在正常生理、病理过程中的作用,如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。