癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
COVID-19 Cytokine Storm Pathway
Activated monocyte-derived macrophages (MDM) contribute to the COVID-19 cytokine storm by releasing massive amounts of pro-inflammatory cytokines. CCL , CC- chemokine ligand; CXCL10, CXC- chemokine ligand 10; ISG, interferon- stimulated gene; ITAM, immunoreceptor tyrosine- based activation motif; TRAM, TRIF- related adaptor molecule. Monocytes differentiate into pro-inflammatory macrophages though activation of Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathways. Activated natural killer (NK) cells and T cells further promote the recruitment and activation of monocyte-derived macrophages through the production of granulocyte–macrophage colony- stimulating factor (GM- CSF), tumor necrosis factor (TNF) and interferon-γ (IFNγ). Oxidized phospholipids (OxPLs) accumulate in infected lungs and activate MDMs through the Toll- like receptor 4 (TLR4)–TRAF6–NF-κB pathway. Virus sensing can trigger TLR7 activation through viral single-stranded RNA recognition. Type-I INF might induce the expression of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) entry receptors (ACE2, CD147), enabling the virus to access the macrophage cytoplasm and activate the NLRP3 inflammasome, leading to the secretion of IL-1β and/or IL-18. The engagement of Fcγ receptors (FcγRs) by anti-spike protein IgG immune complexes can contribute to increased inflammatory activation of MDMs.