癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Interactive NFKappa Pathway
Click on any interested proteinor antibody ID in the NFKappa pathway to list relevant products below.Our team of experts will customize experimental protocol for your research and diagnostics needs.
Nuclear factor-kB (NF-kB)/Rel proteins control genes involved in inflammation, innate and adaptive immunity, B-cell development inflammation, and stress responses. In the canonical NF-kB pathway, IkB proteins bind and inhibit NF-kB/Rel proteins. A host of receptors activate an IKK complex that phosphorylates IkB proteins, triggering ubiquitination and proteasomal degradation, liberating NF-kB/Rel complexes which ultimately migrate to the nucleus to upregulate target gene expression. In the noncanonical pathway, specific receptor signaling activates kinase NIK, which activates IKKa complexes that phosphorylate residues in NF-kB2 p100. This process promotes ubiquitination and proteasomal cleavage to NF-kB2 p52. NF-kB p52/RelB complexes move to the nucleus to induce target gene expression.