Interactive mTOR Signaling Pathway
The mammalian target of rapamycin (mTOR) signaling pathway integrates intracellular and extracellular signals to regulate cell metabolism, growth, proliferation and survival. This pathway is activated during a range of cellular processes (tumor formation, angiogenesis, insulin resistance, adipogenesis, T-lymphocyte activation, etc.) and is dysregulated in diseases such as cancer and diabetes. mTOR inhibitors such as rapamycin and its analogues are used in treatment of solid tumors, organ transplantation, circulatory disease and rheumatoid arthritis.
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癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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