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Mouse Monoclonal Antibody [Clone DCS-6]
Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Mouse Monoclonal Antibody [Clone DCS-6]
Purified Mouse Monoclonal Antibody
![0 - Cyclin D1 (G1-Cyclin & Mantle Cell Marker)
Mouse Monoclonal Antibody [Clone DCS-6]
AH10365](/assets/uploads/products/201506/AH10365_FC_1.jpg)
![0 - Cyclin D1 (G1-Cyclin & Mantle Cell Marker)
Mouse Monoclonal Antibody [Clone DCS-6]
AH10365](/assets/uploads/products/201506/AH10365_FC_2.jpg)
- 产品详情
- 实验流程
Application 
| IF, FC |
|---|---|
| Primary Accession | P24385 |
| Other Accession | P25322, P39948 (Rat) |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a, kappa |
| Clone Names | DCS-6 |
| Calculated MW | 33729 Da |
| Gene ID | 595 |
|---|---|
| Other Names | B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, cD1, Cyl 1, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene |
| Target/Specificity | Human recombinant full length cyclin D1 protein |
| Application Note | low Cytometry (5ul per test per one million cells or 5ul per 100ul of whole blood); Immunofluorescence (1:50-1:100 for 30 minutes at RT)； (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)； Optimal dilution for a specific application should be determined. |
| Format | 0.5ml at 100ug/ml with BSA and azide |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Mouse Monoclonal Antibody [Clone DCS-6] is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCND1 {ECO:0000303|PubMed:8204893, ECO:0000312|HGNC:HGNC:1582} |
|---|---|
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:33854235, PubMed:8114739, PubMed:8302605). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Hypophosphorylates RB1 in early G(1) phase (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8114739, PubMed:8302605). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1827756, PubMed:1833066, PubMed:19412162, PubMed:8302605). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529). |
| Cellular Location | Nucleus. Cytoplasm. Nucleus membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
1. Lukas J, et. al. Oncogene, 1994, 9(3):707-18.
2. Gillett C, et. al. Cancer Research, 1994, 54(7):1812-7.
3. Bartkova J, et. al. Journal of Pathology, 1994, 172(3):237-45.
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